pH-control of swelling and charge neutralization of thin hydrogel films


Hydrogels are widely used in biomaterials science, much due to excellent protein resistance, and physicochemical properties similar to biological tissue. Charge neutrality is essential for protein resistance, and can be achieved with uncharged hydrophilic polymers, but also zwitterionic and other charge-compensated materials are effective in this respect. The presence of a large number of ionizable groups facilitate strong ionic hydration, reducing protein adsorption. However, the neutrality is pH-sensitive, and antifouling properties might not be retained if the pH is changed. We have exploited this pH-sensitivity to develop coatings with pH-tunable protein resistance, formed from layers of oppositely charged polymers. However, our understanding of the charge-neutralization, and the precise relation to polymer composition and intermixing is limited, and will be addressed in this study.

Metadata Access
Creator Mr Bela Nagy; Dr Mario Campana; Mr Mohammad Javad Jafari; Dr Thomas Ederth
Publisher ISIS Neutron and Muon Source
Publication Year 2019
Rights CC-BY Attribution 4.0 International;
OpenAccess true
Contact isisdata(at)
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences
Temporal Coverage Begin 2016-05-13T08:00:00Z
Temporal Coverage End 2016-05-18T08:00:00Z