We present a large dataset of density functional theory calculations of thiophene (C4H4S) adsorbed on metallic and bimetallic (100) surfaces performed in Quantum Espresso. In total 1131 different surfaces were explored resulting in 2235 total calculations. Slabs were built from 37 different possible elements in the stoichiometry of A3B, Ll2 structures. The 37 single element slabs, A1 structures, were included as well. Slabs were cleaved in the (100) direction. Two hollow adsorption sites were chosen to be explored over bimetallic surfaces and one hollow configuration for the single metal surfaces. Bader charge analysis files are also presented.