Controlled drug delivery must be supported by specialized multi-task devices for addressing a predetermined therapeutic dose in controlled physiological conditions. Combining soft-matter and nanofabrications, a series of drug delivery devices with unique features can be obtained. Our group focussed on injectable nano/micro carriers displaying a shrinking behaviour when heated at physiological temperature accompanied by an enhanced release of the drug payload. Diffusion of water in confining systems as microgels is key for engineering this release. QENS has proven to be an invaluable tool to investigate water dynamics at microscopic level. In this study we plan to investigate the behaviour of water caged in dextran based microgels, with enhanced thermoresponsivity. The behaviour of confined water will be studied from 5 to 45 °C in microgel samples at different crosslinking degree.