Here we present the triple isotopic composition of atmospheric oxygen (Δ17O of O2) measured from EPICA Dome C (EDC) ice core, Antarctica, over 58.0-150.0, 233.2-238.1, and 445.6-796.3 ka, in order to reconstruct the past global biosphere productivity (Luz et al., 1999). The data were produced between Feb. 2019 and Oct. 2020 at Laboratoire des Sciences du Climat et de l'Environnement (LSCE), Gif-sur-Yvette, France. The air samples trapped in EDC ice cores were extracted and purified by a semi-automated system of LSCE, following the identical principles of Barkan and Luz (2005).