Ion and temperature effects on the self-assembly of short peptides - SANS studies

DOI

In this work, we have selected a group of 5 short peptides I3GGHK, I4GGHK, I3GGGHK, I3GGHHK and I3KGGH to study how changes in peptide concentration, [Cu2+] and temperature affect their nanostructuring by SANS. Through extensive studies by AFM and TEM, we found that changes in GH position in the sequence can hugely affect nanostructures via altering peptide packing, layer thickness and twisting. These structural effects affect how molecules can align and form layers and extend to higher orders of structures. Because these sizes are in the order of a few nanometers and difficult to image but are ideal for SANS measurements. SANS2D is preferred because of its high structural sensitivity and wider Q range to cover different size ranges. We request 2 days of SANS2d or 4 days of LOQ to complete the work.

Identifier
DOI https://doi.org/10.5286/ISIS.E.RB1920153-1
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/108679414
Provenance
Creator Dr Mingrui Liao; Professor hu zhu; Miss LIN ZHANG; Mr Huayang Liu; Mr kangcheng shen; Dr Laura Fox; Mr KE FA; Miss Meixing Wang; Mr Peter Hollowell; Mr Sean Ruane; Professor Jiqian Wang; Dr Zongyi Li; Dr Robert Dalgliesh; Professor Hai Xu; Professor Jian Lu; Mr Xuzhi Hu
Publisher ISIS Neutron and Muon Source
Publication Year 2022
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Natural Sciences; Physics
Temporal Coverage Begin 2019-11-20T08:30:00Z
Temporal Coverage End 2019-11-23T08:30:00Z