Determination of the total cross sections and the effective temperature of atoms in amorphous pharmaceuticals.

DOI

Until now, substances of pharmacy have been prepared especially in the crystalline state for obvious reasons of stability. Nevertheless, complex active pharmaceutical ingredients are more and more formulated in the amorphous state, because this state exhibits a larger solubility than the crystalline one. There is several methods of amorphisation, and one of the opened question is to know if there is some structural differences between amorphous obtained by different ways. We thus carried out an experiment on D3,ILL aiming to investigate microstructural signature of amorphous obtained by different techniques. However, a proper treatment of the raw datas requires the knowledge of the total cross sections and the effective temperatures of atoms in the system. VESUVIO is particularly suited for measuring such quantities, and is then the instrument of interest in this proposal.

Identifier
DOI https://doi.org/10.5286/ISIS.E.83551367
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/83551367
Provenance
Creator Dr Javier Dawidowski; Dr Frederic Affouard; Mr Frédéric NGONO MEBENGA; Dr Jean-François WILLART; Dr Giovanni Romanelli; Dr Monica Jimenez-Ruiz; Dr Luis Rodríguez Palomino; Dr Gabriel Cuello
Publisher ISIS Neutron and Muon Source
Publication Year 2019
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2016-12-06T09:00:00Z
Temporal Coverage End 2016-12-13T09:00:00Z