We apply a multi-proxy approach to marine sediment core CDH-89 to assess paleoclimate changes in Northeastern Brazil (NEB) and in the western equatorial Atlantic (WEA) during the penultimate deglaciation. WEA bottom water ventilation was reconstructed through two independent proxies: bulk sediment manganese (Mn) content and benthic foraminifera Cibicidoides wuellerstorfi stable carbon isotopic composition. We derived WEA sea surface temperature based on planktonic foraminifera Globigerinoides ruber (white) sensu stricto Mg/Ca. Finally, we reconstructed NEB hydroclimate using two further independent proxies: ln(Ti/Ca) in bulk sediment and quartz luminescence sensitivity calculated through the intensities of the first second of the optically stimulated luminescence (OSL) decay curve and of the 110°C thermoluminescence (TL) peak. Additionally, we applied surface primary productivity and fragmentation indexes in planktonic foraminifera assemblage.