Lipid dynamics in raft domains and effect of an oxidized bilayer component on their formation

DOI

Lipid oxidation is linked to many adverse health effects. In this proposal we will use QENS in combination with contrast variation as a non-invasive method to detect and characterize the presence and size of microdomains formed in vesicles of biologically relevant lipids as a function of oxidized lipid levels and temperature. The domain forming lipid mixture system to be used in the present study will be composed of a saturated phospholipid, DPPC, an unsaturated phospholipid, POPC, and cholesterol (Chol) where a portion of the POPC is systematically replaced with the oxidized version of POPC, POnPC.

Identifier
DOI https://doi.org/10.5286/ISIS.E.87839972
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/87839972
Provenance
Creator Professor Jayne Lawrence; Dr Dave Barlow; Dr Victoria Garcia Sakai; Dr Katherine Thompson; Dr Fabrizia Foglia; Miss Neelam Jhalley; Dr Delaram Ahmadi
Publisher ISIS Neutron and Muon Source
Publication Year 2020
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering
Temporal Coverage Begin 2017-11-30T09:00:00Z
Temporal Coverage End 2017-12-04T10:14:17Z