The Sr-Nd-Pb isotope composition of the siliciclastic sediment fraction of the two marine sediment cores GeoB22346-3 and GeoB22357-3, raised within and off the Clyde Inlet, provide insight into changes in sediment provenances during the late Pleistocene and the Holocene. Variable radiogenic isotope ratios also give evidence about a changing glacier extent on the northeastern Baffin Island and the adjacent shelf as well as changing oceanographic conditions in western Baffin Bay. Sample preparation and radiogenic isotope analysis were conducted in the laboratories of the Isotope Geochemistry Group at MARUM – Center for Marine Environmental Sciences, University of Bremen, Germany. All sediment samples were leached with a NaOH-buffered solution of hydroxylamine hydrochloride and 15% acetic acid to separate the siliciclastic sediment fraction (adapted from Gutjahr et al. 2007, , https://doi.org/10.1016/j.chemgeo.2007.03.021). Sr, Nd, and Pb were separated by column chemistry, and the isotope ratios were measured with a Thermo-Fisher Scientific TRITON Plus thermal ionization mass spectrometer (TIMS).