(Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard

DOI

Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-retardants alter their toxicological properties and these metabolites are known to interfere with the binding of thyroid hormone (TH) to transthyretin (TTR) in rodents and humans. In polar bear plasma samples no binding of [125I]-T4 to TTR was observed after incubation and PAGE separation. Incubation of the plasma samples with [14C]-4-OH-CB107, a compound with a higher binding affinity to TTR than the endogenous ligand T4 resulted in competitive binding as proven by the appearance of a radio labeled TTR peak in the gel. Plasma incubation with T4 up to 1 mM, a concentration that is not physiologically relevant anymore did not result in any visible competition. These results give evidence that the binding sites on TTR for T4 in wild living polar bears are completely saturated. Such saturation of binding sites can explain observed lowered levels of THs and could lead to contaminant transport into the developing fetus.

Concentrations are given per gram wet weight. Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150

Supplement to: Gutleb, Arno C; Cenijn, Peter; van Velzen, Martin; Lie, Elisabeth; Ropstad, Erik; Skaare, Janneche Utne; Malmberg, Tina; Bergman, Åke; Gabrielsen, Geir W; Legler, Juliette (2010): In vitro assay shows that PCB metabolites completely saturate thyroid hormone transport capacity in blood of wild polar bears (Ursus maritimus). Environmental Science & Technology, 44(8), 3149-3154

Identifier
DOI https://doi.org/10.1594/PANGAEA.810387
Related Identifier https://doi.org/10.1021/es903029j
Metadata Access https://ws.pangaea.de/oai/provider?verb=GetRecord&metadataPrefix=datacite4&identifier=oai:pangaea.de:doi:10.1594/PANGAEA.810387
Provenance
Creator Gutleb, Arno C ORCID logo; Cenijn, Peter; van Velzen, Martin; Lie, Elisabeth; Ropstad, Erik; Skaare, Janneche Utne; Malmberg, Tina; Bergman, Åke; Gabrielsen, Geir W; Legler, Juliette ORCID logo
Publisher PANGAEA
Publication Year 2010
Rights Creative Commons Attribution 3.0 Unported; https://creativecommons.org/licenses/by/3.0/
OpenAccess true
Representation
Resource Type Supplementary Dataset; Dataset
Format text/tab-separated-values
Size 82 data points
Discipline Earth System Research
Spatial Coverage (18.010 LON, 78.900 LAT); Svalbard