Extremophiles are organisms which survive and thrive in extreme environments. The proteins from extremophilic organisms have received considerable attention as they are structurally stable and functionally active under extreme physical and chemical conditions. Our goal is to obtain the design principles which accurately describe the interactions which allow extremophilic proteins to be stable and flexible at extreme temperatures. We wish to combine neutron scattering experiments with a range of other experimental and computational tools to provide a complete picture of the protein's structure and dynamics. This will provide fundamental insights into the mechanisms of adaptation of extremophile organisms, in addition to providing a foundation for the development of an understanding of biological molecules that can be exploited in synthetic biology, industry and bionanotechnology.