There is a growing interest to alternative methods to disrupt malaria transmission, such as the use of gut associated microbes that could interfere with the transmission of parasites. Microbial symbionts can confer a fitness gain on their arthropod hosts, influencing nutrition, reproduction, heat tolerance and resistance to pathogens. Symbiotic microorganisms were shown as influencing the vectorial capacity of arthropod disease vectors. Particularlry, gut-inhabiting bacteria have been shown to interfere with parasite transmission in the mosquito. Interestingly, bacterial communities are dominated by widely distributed taxa that appear to colonize hosts opportunistically. The microbes that are widerspread in a large range of hosts are thought to fulfill a functional niche, they may be dependant of the host diet and a better knowledge of bacteria-host interactions is necessary to identify which members or family might be targeted for genetic manipulation or paratransgenesis.