The Harlequin sweetlips, Plectorhinchus Chaetodonoides belongs to the family Haemulidae of order Perciformes, and is a common multicolored sweetlip that is mostly found in the Indo-Western Pacific. Adults are solitary and found near ledges or caves while juveniles have been discovered among corals. Morphologically, external appearance and color patterns in P. Chaetodonoides could change drastically during its growth. Juveniles brownish with large, well-defined creamy-white blotches on body which involves brown spots with age, as it grow to adult, color slowly changing into a greyish background with large, deep-brown spots, making the juvenile quite distinct from its adult form (McKay 1984, 2001). The entire mitochondrial genome of P. chaetodonoides was described in this work.