This work features the development of artificial protein micro-granules for clinical applications, inspired by naturally occurring amyloid structures in bacterial inclusion bodies and mammalian endocrine granules. The authors developed these synthetic granules using a reversible coordination method involving histidine residues and zinc ions (Zn+2). Unlike natural systems, which rely on stereospecificity, the authors demonstrated that their approach allows the formation of hybrid protein materials using two distinct polypeptides, without requiring structural similarities. This method enables the creation of combined protein depots, offering new possibilities for delivering therapeutic proteins in defined ratios and potentially enhancing functional synergies for medical applications.

Fiji, 1.53c

ZS XPLORER, 2.0.1.1

Pending acceptance of related publication.