The interaction of oxidatively damaged lung proteins with anionic lipids


Lung surfactant protein B, SP-B, interacts with lipids at the air-water interface of the lung where its presence is vital for correct respiratory function. SP-B and its synthetically available construct Super-Mini B, SMB, are known to be damaged by exposure to the ubiquitous gas-phase pollutant ozone but remain at the air-water interface in damaged form. The exposure leads to the conversion of neutral side changes into negatively charged side chains. What is less clear is how these damaged peptides interact with negatively charged lipids that are also required at the air-water interface. In this work we will look at the interaction between the initially positively charged peptide SMB and the negatively charged lipid 1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol)], DPPG, before and after exposure to a dilute flow of ozone gas.

Metadata Access
Creator Dr Arwel Hughes; Dr Katherine Thompson; Miss Joanna Hemming; Professor Adrian Rennie
Publisher ISIS Neutron and Muon Source
Publication Year 2015
Rights CC-BY Attribution 4.0 International;
OpenAccess true
Contact isisdata(at)
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2012-06-06T07:57:36Z
Temporal Coverage End 2012-07-21T09:25:47Z