Wittig Reaction: Cleaning up 50 years of Waste in Metal-Free Catalysis

DOI

Our recent works have solved a 50 yr old problem (in part) with computational steering successfully guiding synthetic work towards a wittig process catalytic in phosphine. The work was deemed a ¿hot article¿ in Angewandte Chemie, the impact of which was immediately highlighted in Nature Chemistry and Chemical&Enginnering News. Despite the synthetic successes, the mechanisms by which these reactions proceed are still not well understood, while their selectivity (E vs. Z product) is not known at all. Recent thereotical determinations point to low energy (terahertz) vibrations in the fingerprint region being responsible for product selectivity. Of particular focus is to characterise the differences in structure & dynamics between the traditional PPh3 Wittig reagent and our novel compounds and their oxidised counterparts. We propose to characterise the fingerprint vibration region of each.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24087904
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24087904
Provenance
Creator Professor Stewart Parker; Dr Gregory Chasse; Dr Mauro Fianchini; Mr Elliot Bennett; Dr Christopher O'Brien; Dr Igor Larrosa; Dr Stephen Goldup; Dr Kun Tian; Professor Neville Greaves; Dr Christian Nijhuis; Professor John Nicholson
Publisher ISIS Neutron and Muon Source
Publication Year 2014
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2011-10-10T13:10:57Z
Temporal Coverage End 2011-10-16T02:48:16Z