Dynamics of trehalose-glycerol and lysozyme/trehalose-glycerol mixtures


The proposed experiment aims to study the dynamics of trehalose/glycerol mixtures and lysozyme in presence of trehalose/glycerol mixtures at different relative concentration. The aim is to investigate the coupling between the bioprotectant mixture and the protein and to verify if the dynamics of the system as a function of the trehalose/glycerol concentration shows a slowing down maximum at the concentration value of 0.05 (by weight) for which an anomalous behaviour has been observed by light and neutron scattering. By performing runs of 8 hours and the necessary calibration and empty cell measurements, we estimate a total of 6 days of beam time on IRIS for the required statistics.

DOI https://doi.org/10.5286/ISIS.E.24003091
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24003091
Creator Professor Federica Migliardo; Professor Salvatore Magazu
Publisher ISIS Neutron and Muon Source
Publication Year 2011
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2008-04-29T08:23:25Z
Temporal Coverage End 2008-05-05T04:44:12Z