Dataset associated to : Caillon, C., Pernet, F., Lutier, M., and Di Poi, C. Reaction norms of two oyster species from different habitats in response to ocean acidification, in submission. The database contains data from: 1. seawater physico-chemical parameters during the acclimation period, 2. oyster survival during the acclimation period, 3. biometrics of oyster species, 4. shell coloration of oyster species, 5. composition of the membrane fatty acids of oyster species, 6. temporal evolution of the phytoplankton cell volume, 7. fatty acid composition of phytoplankton, 8. energy reserves of oyster species.