Intron evolution in Saccharomycetaceae

Purpose: Saccharomyceatacea yeast are intron-poor species and they contain on average 300 introns in their genomes. We designed RNAseq experiment to investigate if splicing patterns in related yeast species are similar. Methods: Total RNA was extracted from wild type cells and processed by the RiboMinus Transcriptome Isolation Kit for Yeast and Bacteria (Invitrogen) to deplete the rRNA. cDNA libraries were prepared according to manufacturer's protocol and sequenced by SOLiD. Sequence reads were filtered and processed by TopHat. Results: We found 216, 163, 200 and 155 predicted introns with canonical splice signals in S. cerevisiae, S. kudriavzevii, S. bayanus and N. castellii respectively. Three introns in S. cerevisiae, four in S. bayanus and ten in S. castellii are novel compared to Saccharomyces Genome Database (SGD) annotations. The expression of introns and splicing shows very high correlation between species. Conclusion: Transcripts with introns in yeast species tested show similar levels of expression and splicing. We found few novel introns, which are conserved in yeast genomes. Overall design: Total RNA profiles from wild type yeast S. cerevisiae, S. kudriavzevii, S. bayanus and N. castellii generated by RNAseq using SOLiD.

Identifier
Source https://data.blue-cloud.org/search-details?step=~0122D7C60A3DEB423B5A5E92DDFDCBF8553E5254CAB
Metadata Access https://data.blue-cloud.org/api/collections/2D7C60A3DEB423B5A5E92DDFDCBF8553E5254CAB
Provenance
Instrument AB SOLiD 4 System; ABI_SOLID
Publisher Blue-Cloud Data Discovery & Access service; ELIXIR-ENA
Publication Year 2024
OpenAccess true
Contact blue-cloud-support(at)maris.nl
Representation
Discipline Marine Science
Temporal Point 2014-10-15T00:00:00Z