Optimum Blue Light Exposure: A Means to Increase Cell-Specific Productivity in Chinese Hamster Ovary Cells

DOI

Raw Data for manuscript titled Optimum Blue Light Exposure: A Means to Increase Cell-Specific Productivity in Chinese Hamster Ovary Cells This dataset was generated from experiments conducted in mini bioreactor cultures to investigate the effects of blue light illumination on mammalian cells. The study demonstrated an increase in cell-specific productivity (csp) of monoclonal antibodies under blue light exposure.

The dataset includes: Growth data: Detailed cell growth metrics. Monoclonal antibody titers: Measurements of antibody concentration. Intracellular ROS measurements: Data on reactive oxygen species levels. Cell cycle analysis: Distribution of cells across different phases. QTOF measurements: Proteomic and metabolomic profiling to explore mechanisms behind csp enhancement. All data are presented in tabular format, including means and standard deviations, providing precise numerical values. The dataset is organized by light intensity (W/m²) and light intervals (light/dark cycles) to facilitate analysis of the observed effects.

This repository offers a comprehensive resource for further exploration of light-mediated productivity enhancement in bioprocesses.

Identifier
DOI https://doi.org/10.18419/darus-4449
Related Identifier IsCitedBy https://doi.org/10.1007/s00253-024-13363-4
Metadata Access https://darus.uni-stuttgart.de/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=doi:10.18419/darus-4449
Provenance
Creator Föller, Stefanie ORCID logo; Takors, Ralf ORCID logo; Regett, Niklas ORCID logo; Levin Lataster; Radziwill, Gerald (ORCID: 0000-0002-8793-154X)
Publisher DaRUS
Contributor Föller, Stefanie; Takors, Ralf
Publication Year 2024
Funding Reference DFG 428475642
Rights CC BY 4.0; info:eu-repo/semantics/openAccess; http://creativecommons.org/licenses/by/4.0
OpenAccess true
Contact Föller, Stefanie (Universität Stuttgart); Takors, Ralf (Universität Stuttgart)
Representation
Resource Type Dataset
Format text/comma-separated-values; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Size 2920; 13617; 3622; 16982; 1038; 9789; 1728; 10728; 13118; 19140
Version 1.0
Discipline Biology; Life Sciences; Medicine