Goal of this study was to assess if the (cost-)effectiveness of a personalized physical therapy approach (Coach2Move) compared to usual care physical therapy (UCP), as demonstrated in a previous trial, could be replicated. This was done using a multicenter cluster-randomized stepped wedge trial with four clusters consisting of four physical therapy practices in the Netherlands comparing a personalized physical therapy approach to elicit physical activity (Coach2Move) versus care as usual. Multilevel analyses for effectiveness were conducted for the amount of physical activity (LASA Physical Activity Questionnaire) and functional mobility (Timed Up and Go test) at 3, 6 (primary outcome), and 12 months follow-up. Secondary outcomes were level of frailty (Evaluative Frailty Index for Physical Activity), perceived effect (Global Perceived Effect and Patient Specific Complaints questionnaire), quality of life (EQ-5D-5L) and healthcare expenditures. A total of 292 community-dwelling older adults with mobility problems visiting physical therapists were included in either the Coach2Move (n=112, mean (SD) age 82 (5) years; 60% female) or UCP (n=180, mean age 81 (6) years; 62% female) section of the trial.