INTERACTIONS OF PAMAM DENDRIMERS WITH DESIGNER BIOSURFACTANTS AT THE SOLID/LIQUID INTERFACE

DOI

Poly(amidoamine) (PAMAM) dendrimers have been identified as potential gene vectors. We have studied their association with surfactants, dilauroylphospholiponucleosides (DLPN), with a nucleobase polar head that triggers molecular recognition of DNA and RNA. The interactions of DLPN with pre-adsorbed PAMAM monolayers on silica have been investigated with quartz crystal microbalance with dissipation monitoring (QCM-D), showing the formation of a rigid layer, apparently independent of the DLPN concentration, and a partially irreversible adsorption, but the structure and composition of the layers are not accessible with QCM-D. We aim to investigate the interactions PAMAM/DLPN on silica using neutron reflectivity (NR) at INTER. We plan to employ isotopic solvent contrasts to characterize the adsorbing layers through the simultaneous fittings of corresponding NR profiles in different contrasts.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24090137
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24090137
Provenance
Creator Professor Tommy Nylander; Miss Marianna Yanez; Professor Piero Baglioni
Publisher ISIS Neutron and Muon Source
Publication Year 2016
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2013-03-11T08:59:45Z
Temporal Coverage End 2013-03-15T08:00:35Z