117 datasets found

The objective of the present study is to investigate the interaction between PAMAM dendrimers and solid supported model biomembranes of high fluidity. These membranes consist of...

The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers...

Silver nanoparticles have been shown to have strong antimicrobial effects against many organisms, including those resistant to conventional antibiotics. However, the exact...

Floating bilayers are supported phospholipid membranes, which are minimally constrained by the influence of the substrate, and therefore considered to be more realistic than...

Perfluoroalkyl substances (PFASs) are fully fluorinated, stabile, and surface-active compounds. They contain both a hydrophobic fluorinated carbon chain and an ionizable...

Drug delivery through skin is an important delivery route. However, the outermost layer of the skin provides a formidable barrier to dermal absorption and penetration for...

Perfluoroalkyl substances (PFASs) are used extensively in industrial products although have been identified as emerging pollutants accumulating in wildlife and environment....

Antimicrobial peptides (AMPs) are attractive drug candidates because of their selectivity and speed of action against bacteria. We have developed a novel approach to delivering...

Antimicrobial peptides are small, usually alpha-helical peptides that kill cells by disrupting the cell membrane. Recently, we have been studying a simple 'designed'...

Organic solar cells (OPVs) are photovoltaic devices that can convert the energy from sunlight into electricity and have attracted much attention as a viable green energy source...

Seawater desalination process with reverse osmosis membrane has been widely used to supply high quality water. Over the past decades, despite considerable performance...

There is currly great interest in the use of neutron reflection to study model bilayers. We have produced a model membrane system that is strongly associated with the substrate,...

The Earth¿s climate is strongly influenced by clouds. The oxidative processing of pollutants in clouds affects droplet size and optical properties, important climatic effects....

We recently improved free standing bilayers using a thiolipid layer on gold which also permits magnetic contrast reflectometry. One use for this system is to contribute to our...

The complex sample environment needed for floating supported bilayers has often led to a need to constantly redevelop the system to improve reproducibility. Here we plan to...

Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a...

Oxidation of membrane lipids by Reactive Oxygen Species, ROS, in cells may impact ageing, cell apoptosis and cancer. We propose to use our skills obtained studying the oxidation...

The Arctic climate is strongly influenced by clouds. The oxidative processing of pollutants in Arctic clouds affects droplet size and optical properties, important climatic...

In this work we will explore how to use PolRef to study the binding of our rationally designed peptide amphiphiles onto floating lipid bilayers mimicking G- bacterial and red...

Plastic bags are used as containers for storage of donated blood. These bags are typically made out of PVC plasticized with dialkylphthalates (e.g. DEHP), which migrates into...