-
Curvature effects in polyelectrolyte-surfactant solution interactions
This proposal continues our investigations into polyelectrolyte-surfactant solutions which form thin films at the air-solution interface. Our previous work has investigated the... -
Structural origin of anomalous relaxation behaviour in alcohol-water mixtures
In recent dielectric and calorimetric studies of some alcohol-water mixtures we have discovered unexpected and unexplained relaxation behaviours. Our aim with this proposal is... -
Unravelling the thermal denaturation and stability of the solution structures...
The glycosylation of glycoproteins is a major determinant of their stability, and glycans also affect their aggregatibility (precipitation). An understanding of this is... -
Control of shish formation in semicrystalline polymers
Measurements of shish structure in semicrystalline polymers after controlled shear-induced crystallizationA combinatorial approach developed to find the boundary conditions for... -
Exchange kinetics of complex coacervates core micelles
Coacervates have been studied for a long time for their unusual properties: they are dense networks of charged polymers that are soluble in water. Instead of flocculating when... -
A SANS study of nano-gels with a temperature tunable bio-interface
Hyaluronic acid (HA) plays a key role in tumour cell bio-adhesion and, as such, this interaction opens up possibilities for targeted tumour pathologies We have created a... -
Effect of End Group on RAFT-Polymers for Lipid Nanodisc Stabilisation
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Previously we studied discs formed using... -
Structure of Cellulose Nanofibril Gels
This proposal is part of a new project based on understanding the formation of gels in suspensions of partially oxidised cellulose nanofibrils with small amounts of salt or... -
SANS Investigation into the Mode of Interaction between Antibiotics and Diffe...
In this part of proposed work, we wish to explore how antibiotics minocycline and tetracycline interact with model lipid bilayers in the form of SUVs, mimicking key features of... -
Correlating the Internal Structure of Drug-Loaded Polymeric Nanoparticles to ...
The understanding the drug release mechanism from polymeric nanoparticles (PNPs) requires a detailed characterisation of the PNPs internal structure. Small-angle neutron... -
Compartmentalised Supramolecular Structures through CB[8]-mediated Hierarchic...
We have recently developed a method to prepare a wide variety of amphiphilic diblock copolymers through a supramolecular linkage that is stable in water. This has been achieved... -
Stabilising emulsions with protein-surfactant mixtures.
Hydrophobins, hfb2, are secreted fungal proteins, which are strongly surface active and possess powerful emulsion and foam stabilising properties. Understanding their... -
Use of nitric oxide radicals for the formation of a supramolecular hydrogel
The aim of this proposal is to study the structure of hydrogel systems formed from fluorenylmethyloxycarbonyl (FMOC) protected peptides, via the use of nitric oxide radicals.... -
Micellar modifiers for CO2
This proposal focuses on a new approach to the formation of rod-like micelles in supercritical CO2 (scCO2). Recent successful high-pressure SANS (HP-SANS) results have shown for... -
Kinetic studies of the Trost ligand particpating in a catalytic cycle
The aim is use time-resolved SANS to monitor the changes in aggregation structure of the Trost ligand[1] Pd-catalyst [(DACH-phenyl-TSL)Pd+(η3-C6H9)]BArF- 1 (Figure 1 left)... -
Structural and thermodynamic properties of EVOH (ethylene-vinyl alcohol) base...
Poly(vinyl alcohol) is a biocompatible water-soluble polymer of great interest thanks to its large-scale applications for production of drug-delivery systems, sensors or... -
Surfactant induced gelation of TEMPO-oxidized cellulose; Using betaine-based ...
Our group has been working cellulose nanofibrils (OCNF) which form hydrogels in the presence of certain additives. Previously, we have studied the effect of salt, single... -
Combined SAXS and SANS analysis of strained composite materials
The microscopic origins of strain softening (Payne Effect) are vital to our understanding of energy dissipation in vehicle tyres. This proposal builds on our recent SANS... -
Is there a CMC for surfactants in non-aqueous solvents?
The aim of this project is to use SANS to determine if a critical micelle concentration (CMC) exists for the formation of inverse micelles in non-polar solvents. The CMC is a... -
Dynamics of chain exchange between stiff complex coarcervate core micelles (C...
Complex coacervates core micelles (C3Ms) are colloids obtained through the co-assembly of neutral-ionic copolymers bearing oppositely charged functional groups. These micelles...