-
Effect of drug on the micelles formed by ionic surfactants
The aim of the study is to use SANS in combination with contrast variation to determine the effect of solubilising the lipophilic drug, testosterone propionate, in micelles... -
Molecular architecture of vesicles formed by novel sterol-modified phospholipids
A family of sterol-modified glycerophospholipids (SML) have been synthesized in which the sn-1 or sn-2 position is covalently attached to cholesterol and the alternative... -
Microdomains in model membranes using contrast variation SANS
In the present proposal small angle neutron scattering will be used in combination with contrast variation as a non-invasive method to detect the presence and size formation of... -
Effect of reversing lipid head group charge on vesicular properties
Zwitterionic lipids such as phosphatidylcholine (PC) are major components of the membranes that compartmentalize organisms. Although there is a large literature on PC, cationic... -
Conformational change of glycerol faciliitator protein on substrate binding
A large family of membrane channel proteins selective for transport of water (aquaporins) or water plus glycerol (aquaglyceroporins) has been found in diverse life forms. E.... -
SANS studies of phospholipid:sterol vesicles and the membrane interactions of...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
Effect of surfactant head group on micelle structure of drug containing micelles
The aim of the current project is to probe (at the nanometer length scale) the relationship between the solution structures of a surfactant molecule, the aggregate(s) it forms... -
Molecular architecture of monolayers formed by novel sterol-modified phosphol...
A family of sterol-modified glycerophospholipids (SML) have been synthesized in which the sn-1 or sn-2 position is covalently attached to cholesterol and the alternative... -
Planar bilayer formation on novel cationic surface suitable for membrane prot...
Membrane receptor proteins (MRPs) which are thought to represent the majority of drug targets are challenging to study as their structure and function is dependent on being... -
The calcuim mediation interaction of DNA with monolayers of DSPC and DOPE
The main objective of the present work is to complete some work aimed at gaining an understanding of the interaction of phospholipid membranes containing the neutral helper... -
SANS studies of mixed phospholipid:sterol vesicles and their interaction with...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
Probing the internal structure of gene delivery vehicles using contrast varia...
Gene delivery vehicles, known as LPD complexes, prepared from mixing cationic lipid vesicles (L) with cationic peptide (P) and DNA (D) have proven to be very effective at... -
Kinetics of amphotericin B interaction with model human and fungal cell membr...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents. The successful development of... -
SANS studies of Amphotec (aggregates of amphotericin-cholesteryl sulfate)
The anti-fungal agent amphotericin B (AmB) can be administered to patients in aqueous solution complexed with cholesteryl sulfate (CS), and this formulation helps to minimise... -
The effect of anionic lipid unsaturation on the interaction with cytochrome c
While peripheral membrane protein-lipid interactions were originally considered to be solely electrostatic in nature, it is now accepted that they encompass more complicated,... -
Probing the internal structure of ethyl butyrate containing microemulsions us...
The proposal aims to establish the location of the oil, ethyl butyrate in dodecyldimethylamine-N-oxide (DDAO) microemulsions. Molecular dynamic simulations have proposed that a... -
Magnetic study of the new skyrmion-carrying material CoZnMn
Nanoscale magnetic skyrmions are swirl-like magnetisation entities that satisfy topological quantisation conditions. They can therefore not be easily unwound into another... -
Neutron reflectivity studies of the interaction of amphotericin with model ce...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin (AmB) has created a demand for novel anti-fungal agents that can circumvent the pathogens¿... -
SANS studies of mixed phsopholipid:sterol vesicles and their interaction with...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
Neutron reflectivity studies of the interaction of amphotericin with phosphol...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin (AmB) has created a demand for novel anti-fungal agents that can circumvent the pathogens¿...
