SANS studies of mixed phospholipid:sterol vesicles and their interaction with Amphotericin

DOI

The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the pathogens¿ resistance, and the successful development of such compounds will clearly require an understanding of the drug¿s mechanism of action at the molecular level. It has long been held that AmB exerts its anti-fungal action through generation of self-assembled ion channels formed in the ergosterol-containing fungal cell membranes, but not in the cholesterol-containing human cell membranes. There is no direct structural evidence to support this hypothesis, however, and recent research suggests it is seriously flawed. In the SANS studies proposed here, we seek to understand how differences in a sterol¿s chemistry influence its effects on biomembrane structure, and how this then affects the membrane interactions with AmB

Identifier
DOI https://doi.org/10.5286/ISIS.E.24077957
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24077957
Provenance
Creator Professor Jayne Lawrence; Dr Dave Barlow; Ms Fabrizia Foglia
Publisher ISIS Neutron and Muon Source
Publication Year 2012
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2009-11-12T01:37:20Z
Temporal Coverage End 2009-11-14T18:05:12Z