Polymer therapeutic describes polymeric drugs, polymer-drug conjugates, polymer-protein conjugates, polymeric micelles to which drug is covalently bound, and multicomponent polyplexes that are being developed as non-viral vectors. Following selective uptake into the tumour tissue via the enhanced permeability and retention (EPR) effect, polymer therapeutics follow an endocytic route, leading to lysosomes. A drop in pH in late endosomal/lysosomal compartments is used to cleave the linker attaching the anticancer drug to the polymeric carrier. In this project, we explore the use of a heterodimeric coiled coil motif as a non-covalent linker for the construction of non-covalent polymer therapeutics. Here, we wish to probe the solution conformation of a series of non-covalent conjugates as a function of monomer-peptide loading, and degree of inclusion of the coiled coil motif.