Replication Data for Profiling Bitter Taste Receptors (TAS2R) along the Gastrointestinal Tract and their Influence on Enterohormone Secretion. Gender- and Age-Related Effects in the Colon

DOI

This dataset was created for the purpose of analyzing data that was published in the article titled "Profiling Bitter Taste Receptors (TAS2R) along the Gastrointestinal Tract and their Influence on Enterohormone Secretion. Gender- and Age-Related Effects in the Colon". The aim for this dataset was to describe the presence of different bitter taste receptors (TAS2Rs) in different segments of the gastrointestinal tract (GIT), the effect of ageing, location (ascending/descending colon) and sex on the expression of these receptors in the human colon, the expression of these receptors in a cellular study model (HuTu-80 ) and the effect of specific bitter agonists on the secretion of enterohormone GLP-1 in the cellular model. It contains the Ct numbers of the expression of samples in different segments of the GIT, some basic information of the samples obtained from colon for the purpose of identifying their study cohort, the expression Ct numbers of the bitter taste receptors in the cellular model, and the levels of GLP-1 secreted from the cells after stimulation with specific bitter ligands.

The publication is in the process of being published.

This database contains the following type of data: - General information about the participants of the Colon Cohort - Gene expression (Ct) values for different tissues and Cells - Secretion levels of GLP-1 in cells

Identifier
DOI https://doi.org/10.34810/data1647
Metadata Access https://dataverse.csuc.cat/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=doi:10.34810/data1647
Provenance
Creator Jalsevac, Florijan ORCID logo; Descamps-Solà, Maria ORCID logo; Grau-Bové, Carme ORCID logo; Segú, Helena (ORCID: 0000-0001-8892-052X); Auguet, Teresa ORCID logo; Avilés-Jurado, Francesc Xavier ORCID logo; Balaguer, Francesc ORCID logo; Jorba, Rosa ORCID logo; Beltrán-Debón, Raúl ORCID logo; Blay, Maria Teresa ORCID logo; Terra, Ximena ORCID logo; Pinent, Montserrat ORCID logo; Ardévol, Anna ORCID logo
Publisher CORA.Repositori de Dades de Recerca
Contributor Jalsevac, Florijan; Universitat Rovira i Virgili
Publication Year 2024
Funding Reference European Union, Rovira i Virgili University 945413
Rights CC BY-NC 4.0; info:eu-repo/semantics/openAccess; http://creativecommons.org/licenses/by-nc/4.0
OpenAccess true
Contact Jalsevac, Florijan (Universitat Rovira i Virgili)
Representation
Resource Type Experimental data; Dataset
Format text/tab-separated-values; text/plain
Size 1197; 1206; 1210; 581; 1201; 928; 1203; 17142; 458; 1316; 90; 315; 282; 317; 1077; 620; 518; 461; 1311; 517; 319; 88; 519; 746; 958; 621; 89; 450; 911; 311; 1075; 455; 1076; 313; 485; 285; 749; 482; 611; 1310; 957; 454; 309
Version 1.0
Discipline Life Sciences; Medicine