Metatranscriptome: Modulation of small intestinal microbial activity induced by 2 weeks consumption with 2 fermented milk products; a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients

DOI

Ileostomy effluent samples were collected for metatranscriptomic profiling. The samples were collected for the INSIDE explorative diatry study. The study was aimed to characterize the impact of fermented food may have on the small intestinal microbiota and systematically.Please note: the data files belonging to this dataset comprise a total size of 173 GB. Due to its size, the data is archived on DANS secure storage outside of EASY. A file list with an overview of all available files is available on the Data files tab. Please contact DANS in order to obtain acccess to the files.

Date Submitted: 2021-11-23

INSIDE project: Ileostomy-cohort-study-with-two-probiotics, a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients Information: The aim of the study is to determine the small intestinal microbiota response in humans to probiotic supplement interventions for two consecutive weeks, and to relate this to intestinal barrier function and immune and metabolic responses in blood, as functional outcome parameters of host physiology. A small cohort of ileostoma subjects has been recruited to participate in a three-arm intervention trial according to a double blind, cross-over, placebo-controlled design. Two probiotics products and a placebo were administered in random order to each volunteer for two weeks with 2 week wash-out periods in between interventions. The volunteers will participate in this study for approx. 100 days and will, in addition to the three interventions, not consume fermented products.

Identifier
DOI https://doi.org/10.17026/dans-xvh-yww8
Metadata Access https://lifesciences.datastations.nl/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=doi:10.17026/dans-xvh-yww8
Provenance
Creator E. Zaccaria; T. Klaassen; A.M.E. Alleleyn; J. Boekhorst; T. Smokvina; M. Kleerebezem; F.J. Troost
Publisher DANS Data Station Life Sciences
Contributor Data Librarian; Wageningen University & Research
Publication Year 2021
Rights CC BY 4.0; info:eu-repo/semantics/openAccess; http://creativecommons.org/licenses/by/4.0
OpenAccess true
Contact Data Librarian (Wageningen UR)
Representation
Resource Type Dataset
Format application/zip; text/csv
Size 15775; 15377
Version 1.1
Discipline Life Sciences; Medicine