Multiple metagenomes were sequenced from sediments collected from Hydrate Ridge methane seeps. These communities contain organisms performing the anaerobic oxidation of methane (AOM). Our goal was to analyzed the metabolic potential of these organisms and to correlate this genomic information with complementary transcriptomics and proteomics from the same communities #3730 refers to push core (PC) 16 collected during Alvin dive 4635 at Hydrate Ridge South (44° 34.20’ N, 125° 8.87’ W, 775 m depth) from a site of active methane seepage. #5133 refers to elevator 3A push core 47, collected at Hydrate Ridge North during Jason II dive J2-593 from an area of active seepage marked by bubble ebullition and surface expression of white microbial mat (44° 40.17’ N, 125° 5.89’ W, 600 m depth). #5133 contained 9 cm of sediment. #5579 refer to elevator 3A push core 41, collected at Hydrate Ridge North during Jason II dive J2-593 from an area of active seepage marked by bubble ebullition and surface expression of white microbial mat (44° 40.17’ N, 125° 5.89’ W, 600 m depth). #5579 contained 12 cm of sediment.