Structural comparison of peptidomimetic building blocks

DOI

Peptidomimetics are synthetic mimics of peptides, the natural building blocks of proteins, and their development is a growing field of science. An underlying theme in recent peptidomimetic research is the connection between function and structure. For their potential to be fully exploited, a detailed understanding of their structure and interactions is required. In this proposal we will complete solution-based structural investigations of L-Alanine and its comparable analogues, β-alanine and the alanine-monopeptoid, sarcosine. We aim to answer the following questions:i)How do alanine, β¿alanine and sarcosine differ in structure in solution at the atomic level?ii)How are the three analogues hydrated?iii)What important monomer-monomer interactions are there for each analogue solution?These experiments will provide a structural benchmark for all our future studies.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24090559
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24090559
Provenance
Creator Dr James Towey; Professor Lorna Dougan; Dr Natasha Rhys; Professor Alan Soper
Publisher ISIS Neutron and Muon Source
Publication Year 2016
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2013-06-05T13:25:38Z
Temporal Coverage End 2013-06-14T08:35:18Z