This work was conducted in Moorea, French Polynesia to investigate the interacting effects of multiple stressors on the coral microbiome. The coral Pocillopora meandrina was fragmented into mesocosm tanks and subjected to thermal stress, nitrate or ammonium enrichment, and manual scarring for 21 days. DNA samples were taken after the treatment period and 16S libraries were prepared and sequenced. This work adds to our understanding of how multiple local and global stressors interact to cause changes in the coral microbiome.