The effect of fatty acids on the adsorption of HSA at the silica water interface


The primary biological function of albumins is to be fatty acid carriers. The complexation of fatty acids to the albumin is expected to have a strong effect on its adsorption properties. We propose to use neutron reflectometry to probe the surface changes accompanying fatty acid adsorption on the silica (if it occurs) and incorporation of fatty acid into HSA as a function of pH and composition. We will use contrast variation in the fatty acid to discriminate its behaviour from that of the HSA.

Metadata Access
Creator Dr Edward Latter; Professor Jeff Penfold; Dr Bob Thomas
Publisher ISIS Neutron and Muon Source
Publication Year 2012
Rights CC-BY Attribution 4.0 International;
OpenAccess true
Contact isisdata(at)
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2009-06-09T07:45:07Z
Temporal Coverage End 2009-06-11T06:50:56Z