Assessing the interactions of cyclic peptide-polymer conjugates with a lipid bilayer

DOI

Cyclic peptide-polymer nanotubes can readily self-assembly into long nanotubes, and are being extensively studied for drug delivery applications. As such, understanding how these systems behave when interacting with a cell membrane is of critical importance. Recently, we have shown that different polymer-peptide compositions have very different cell-uptake properties, whilst remaining non-toxic. Here we wish to study how different conjugates interact with a lipid bilayer and understand the kinetics and mechanisms of these interactions. Using this information we can develop a more novel range of cyclic peptide nanotubes with the goal of designing systems able to readily assemble and disassembly in the cell membrane without any adverse toxicity effects.

Identifier
DOI https://doi.org/10.5286/ISIS.E.95671062
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/95671062
Provenance
Creator Dr Mario Campana; Mr Sean Heinere Tivini Robert Ellacott; Professor Sebastien Perrier; Miss Agnes Kuroki; Dr Ed Mansfield; Dr Raoul Peltier; Dr Carlos Sanchez-Cano
Publisher ISIS Neutron and Muon Source
Publication Year 2021
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences
Temporal Coverage Begin 2018-06-23T08:00:00Z
Temporal Coverage End 2018-06-25T08:13:02Z