Here, we compile an extensive global surface sediment dataset of OH-isoGDGTs as well as regular isoprenoid GDGTs (isoGDGTs), with both data generated at NIOZ and previously published data from other laboratories. We explore recently developed temperature proxies based on hydroxylated isoprenoid Glycerol Dialkyl Glycerol Tetraethers (OH-isoGDGTs), such as %OH, RI-OH, RI-OH' and OHC for their potential for reconstructing past temperature changes. The data contains surface sediment data from the global ocean used in the study 'Evaluating isoprenoidal hydroxylated GDGT-based temperature proxies in surface sediments from the global ocean'. The excel sheet contains information regarding the surface sediments, their location, enivironmental parameters from each location extracted from WOA database, peak area of iso-GDGTs and OH-isoGDGTs, proxy indices discussed in the study and references for previously published data.