Adsorption of Monoclonal Antibodies at the Solid/liquid Interface

DOI

We propose to use neutron reflection to study the interfacial adsorption of 2 novel bispecific therapeutic antibodies at the silicon oxide/water interface. To enpower each of these antibodies with 2 functional targets, the antibodies have been bioengineered with additional domains and as a result, their structural stability may alter. Current ellipsometric studies have revealed different dynamic adsorption and greater adsorbed amounts at equilibration. The aim of the neutron study is to reveal structural details against concentration, pH and ionic strength and how these factors affect their extent of desorption.

Identifier
DOI https://doi.org/10.5286/ISIS.E.79108844
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/79108844
Provenance
Creator Dr Zongyi Li; Mr Ruiheng Li; Dr Lisa Pan; Mr Robert Holman; Professor Jian Lu; Dr John Webster; Dr Mario Campana; Dr Chris van der Walle
Publisher ISIS Neutron and Muon Source
Publication Year 2019
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Natural Sciences; Physics
Temporal Coverage Begin 2016-04-20T08:00:00Z
Temporal Coverage End 2016-04-24T08:00:00Z