The data held in this repository relate to the manuscript J. Hirschinger, U. Höfle, A. Sánchez-Cano, C. Guinat, G. Croville , M. Barral, J.A. Donázar, C. Le Gall Ladevèze, M. Walch, V. Alvarez, X. Gerrikagoitia, L. Du Plessis, S. Dellicour, E Arrondo, J.A. Sánchez-Zapata, A. Cortés-Avizanda, S. Minayo, J. Tornos, S. Perret, T. Boulinier, P. Orabi, A. Van De Wiele, J.L. Guerin, O. Duriez, G. Le Loc'h. Multidisciplinary tracking of a highly pathogenic avian influenza H5N1 outbreak in Griffon vultures in Southern Europe, 2022.