The influence of transmembrane potential on the orientation of antimicrobial peptide


Natural antimicrobials are of great interest, since they are antibiotics that act on the biological membrane, and it is believed that this makes it far more difficult for organisms to develop resistance to them. A mechanism has been proposed for the method of action of these peptides which has, as its major feature, a reorientation of the peptides from the plane of the bilayer to transbilayer under the influence of an applied voltage. However, this mechanism has not been proved. In 2002, we carried out some preliminary measurements at the ILL which seemed to confirm the reorientation hypothesis. However, due to severe difficulties with our bilayer fabrication protocols at that time, the data is not complete and needs to be repeated. We have now refined our bilayer fabrication protocols so that we are in a poition to repeat these measurements and confirm or refute the rotation hypothesis.

Metadata Access
Creator Professor Jeremy Bradshaw; Dr Arwel Hughes; Dr Stephen Roser
Publisher ISIS Neutron and Muon Source
Publication Year 2012
Rights CC-BY Attribution 4.0 International;
OpenAccess true
Contact isisdata(at)
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2008-02-20T02:58:38Z
Temporal Coverage End 2009-02-11T18:48:36Z